Bt resistance is a phenomenon where certain insects, typically pests, develop resistance to Bacillus thuringiensis (Bt) toxins. Bt toxins are naturally occurring proteins produced by the soil bacterium, Bacillus thuringiensis, and are widely used in agriculture as biopesticides to control insect pests. The development of resistance to Bt toxins is a significant concern in the agricultural industry as it can lead to decreased efficacy of Bt-based pest control methods and increase the need for chemical insecticides. Bt resistance can occur through various mechanisms, such as changes in insect detoxification enzymes, genetic mutations that alter the insect's susceptibility to the toxin, and changes in the binding sites of Bt toxins on insect gut receptors. Researchers studying Bt resistance aim to understand the mechanisms underlying resistance development, monitor resistance levels in pest populations, and develop strategies to combat and manage resistance. This may involve implementing resistance management tactics such as integrating different control methods, rotating Bt toxins, and implementing refuge areas where non-resistant insects can survive and reproduce. The goal of research in this area is to ensure the long-term efficacy and sustainability of Bt-based pest control in agriculture.